本文由小咖机器人翻译整理

期刊来源：Nat Med

原文链接：https://doi.org/10.1038/s41591-023-02731-8

摘要内容如下：

步态冻结（FOG）是帕金森病患者的一种严重的破坏性步态障碍，会导致行走时意外停止。对雾的治疗显示出适度和短暂的影响，导致缺乏有效的治疗方法。在这里，我们展示了概念证明，雾可以避免使用柔软的机器人服装，增加髋关节屈曲。这种可穿戴服装使用电缆驱动的致动器和传感器，与生物肌肉协同产生辅助力矩。在这项为期6个月的5次重复测量的N-of-1试验中，一名患有帕金森氏症和大量雾的73岁男性对机器人服装表现出强烈的反应。在有辅助的情况下，在室内行走过程中，雾被瞬间消除（0%对39±16%的无辅助冻结时间），与无辅助行走相比，行走距离增加了49±11m（+55%），速度更快（+0.18ms-1），步态质量得到改善（步态变异性-25%）。雾目标效应可在多天内重复，激发条件和环境背景，展示了社区使用的潜力。这项研究表明，在患有帕金森氏症的个体中，使用柔软的机器人服装可以避免雾，这推动了技术进步，以应对这一严重但尚未得到满足的需求。

英文原文如下：

Abstracts

Freezing of gait (FoG) is a profoundly disruptive gait disturbance in Parkinson's disease, causing unintended stops while walking. Therapies for FoG reveal modest and transient effects, resulting in a lack of effective treatments. Here we show proof of concept that FoG can be averted using soft robotic apparel that augments hip flexion. The wearable garment uses cable-driven actuators and sensors, generating assistive moments in concert with biological muscles. In this n-of-1 trial with five repeated measurements spanning 6 months, a 73-year-old male with Parkinson's disease and substantial FoG demonstrated a robust response to robotic apparel. With assistance, FoG was instantaneously eliminated during indoor walking (0% versus 39 ± 16% time spent freezing when unassisted), accompanied by 49 ± 11 m (+55%) farther walking compared to unassisted walking, faster speeds (+0.18 m s-1) and improved gait quality (-25% in gait variability). FoG-targeting effects were repeatable across multiple days, provoking conditions and environment contexts, demonstrating potential for community use. This study demonstrated that FoG was averted using soft robotic apparel in an individual with Parkinson's disease, serving as an impetus for technological advancements in response to this serious yet unmet need.

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