本文由小咖机器人翻译整理

期刊来源：N Engl J Med

原文链接：https://doi.org/10.1056/NEJMoa2308192

摘要内容如下：

在墨西哥接受硬膜外麻醉手术的免疫功能正常的患者中，发生了医院内镰刀菌脑膜炎的跨国爆发。所涉及的病原体在脑干和椎基底动脉系统中有很高的偏好，并与血管损伤的高死亡率相关。有效的治疗选择仍然有限；该菌的体外药敏试验表明，它对美国目前批准的所有抗真菌药物具有耐药性。为了强调以这种方式获得的镰刀菌感染相关的严重并发症，我们报告了疫情中13名患者的数据、临床过程和结果，这些患者在平均延迟39天后出现症状。

英文原文如下：

Abstracts

A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.

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