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期刊来源：BMJ

原文链接：https://doi.org/10.1136/bmj-2023-070920

摘要内容如下：

慢性胰腺炎是由于反复发作的胰腺炎症和相关的纤维化导致胰腺外分泌和内分泌功能丧失所致。该疾病表现为腹痛、生活质量恶化、食物消化不良和吸收不良、糖尿病以及胰腺癌风险增加。这篇综述总结了慢性胰腺炎诊断和治疗的最新证据及其表现。特别是，这篇综述讨论了对遗传疾病在疾病机制中的作用的理解进展，以及对药物治疗无效的患者的手术选择。此外，正在进行临床试验，以开发医疗疗法。

英文原文如下：

Abstracts

Chronic pancreatitis results from repeated episodes of pancreatic inflammation and associated fibrosis leading to the loss of functional exocrine and endocrine pancreatic function. The disease is manifested by abdominal pain, deterioration in quality of life, food maldigestion and malabsorption, diabetes, and an increased risk for pancreatic adenocarcinoma. This review summarizes the latest evidence on the diagnosis and management of chronic pancreatitis and its manifestations. In particular, this review discusses advances in understanding of the role of genetic disorders in the mechanisms of the disease and surgical options for patients refractory to medical therapy. Furthermore, clinical trials are under way to develop medical therapeutics.

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