本文由小咖机器人翻译整理

期刊来源：Lancet

原文链接：https://doi.org/10.1016/S0140-6736(24)00016-3

摘要内容如下：

肺的发育始于子宫内，从儿童期一直持续到青春期，在成年早期达到顶峰。由于生理性肺老化，这种增长之后是逐渐下降。在生命过程中，多种宿主和环境因素可改变肺功能的发育。因此，人群中存在一系列肺功能轨迹。低于平均水平的轨迹与呼吸、心血管、代谢和精神健康合并症以及过早死亡有关。这篇综述介绍了肺功能轨迹的研究进展，并有助于在临床实践中将这一知识作为一种创新方法来早期发现肺部健康状况不佳、监测呼吸系统疾病进展和促进肺部健康。具体而言，我们建议，与全球用于监测儿童生长的儿科身高和体重图表类似，肺功能图表可用于儿童和成人，以监测整个生命过程中的肺部健康状况。为了实现这一建议，我们推出了免费的在线肺功能跟踪工具。最后，我们讨论了在人口层面有效实施轨迹概念的挑战和机遇，并概述了支持这种实施所需的关键研究议程。

英文原文如下：

Abstracts

Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death. This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health. Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children's growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course. To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.

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