本文由小咖机器人翻译整理

期刊来源：Lancet

原文链接：https://doi.org/10.1016/S0140-6736(24)00342-8

摘要内容如下：

垂体前叶或垂体后叶激素分泌的部分或完全缺乏导致中枢性肾上腺功能减退、中枢性甲状腺功能减退、低促性腺激素性腺功能减退、生长激素缺乏或精氨酸加压素缺乏，具体取决于受影响的激素。垂体功能减退症是一种罕见的疾病，很可能诊断不全，发病率和患病率虽然未知，但仍在上升。最常见的原因是垂体或下丘脑肿块的压迫性生长或消融。不太常见的原因包括基因突变、垂体炎（尤其是在癌症免疫治疗的情况下）、浸润性和感染性疾病以及创伤性脑损伤。临床特征因发病时间、原因和垂体轴中断的数量而异。诊断需要测量基础循环激素浓度，并根据需要进行确证性激素刺激试验。治疗的目的是补充缺乏的激素。尽管进行了治疗，但死亡率的增加可能会持续存在，特别是在年轻患者、女性患者和精氨酸加压素缺乏症患者中。诊断复杂的患者、妊娠患者和过渡到成年的青少年垂体缺陷患者最好在垂体瘤卓越中心接受治疗。

英文原文如下：

Abstracts

Partial or complete deficiency of anterior or posterior pituitary hormone production leads to central hypoadrenalism, central hypothyroidism, hypogonadotropic hypogonadism, growth hormone deficiency, or arginine vasopressin deficiency depending on the hormones affected. Hypopituitarism is rare and likely to be underdiagnosed, with an unknown but rising incidence and prevalence. The most common cause is compressive growth or ablation of a pituitary or hypothalamic mass. Less common causes include genetic mutations, hypophysitis (especially in the context of cancer immunotherapy), infiltrative and infectious disease, and traumatic brain injury. Clinical features vary with timing of onset, cause, and number of pituitary axes disrupted. Diagnosis requires measurement of basal circulating hormone concentrations and confirmatory hormone stimulation testing as needed. Treatment is aimed at replacement of deficient hormones. Increased mortality might persist despite treatment, particularly in younger patients, females, and those with arginine vasopressin deficiency. Patients with complex diagnoses, pregnant patients, and adolescent pituitary-deficient patients transitioning to adulthood should ideally be managed at a pituitary tumour centre of excellence.

-----------分割线---------

点击链接：https://www.mediecogroup.com/community/user/vip/categories/ ，成为医咖会员，获取12项专属权益。