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期刊来源：Nat Med

原文链接：https://doi.org/10.1038/s41591-024-03002-w

摘要内容如下：

热暴露与早产（PTB）风险增加有关，先前的研究表明，母亲的血压可能在这些关联中发挥作用。2015年至2018年，我们对中国8个省份的197，080名单胎活产婴儿进行了队列研究。该研究首先评估了热暴露、母亲高血压和肺结核临床亚型之间的关系，然后使用中介分析量化了母亲高血压在热暴露和肺结核中的作用。我们发现，从受孕到第20孕周的热暴露（局部温度分布>第85、90和95百分位数）与肺结核增加15-21%和医学指征肺结核增加20-22%相关。热暴露很可能会增加母亲患高血压和血压升高的风险。热暴露（>90%）对肺结核和有医学指征的肺结核的影响中，母体高血压分别占15.7%和33.9%。基于这项大人群研究，我们发现妊娠早期暴露于高温可增加母体高血压的风险，从而影响PTB的发病率。

英文原文如下：

Abstracts

Heat exposure is associated with an increased risk of preterm birth (PTB), with previous work suggesting that maternal blood pressure may play a role in these associations. Here we conducted a cohort study of 197,080 singleton live births across 8 provinces in China from 2015 to 2018. The study first estimated the associations between heat exposure, maternal hypertension and clinical subtypes of PTB, and then quantified the role of maternal hypertension in heat and PTB using mediation analyses. We show that heat exposure (>85th, 90th and 95th percentiles of local temperature distributions) spanning from conception to the 20th gestational week was associated with a 15-21% increase in PTB, and a 20-22% increase in medically indicated PTB. Heat exposure is likely to increase the risk of maternal hypertension and elevated blood pressure. Maternal hypertension mediated 15.7% and 33.9% of the effects of heat exposure (>90th percentile) on PTB and medically indicated PTB, respectively. Based on this large-population study, we found that exposure to heat in early pregnancy can increase the risk of maternal hypertension, thereby affecting the incidence of PTB.

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