本文由小咖机器人翻译整理

期刊来源：Nat Med

原文链接：https://doi.org/10.1038/s41591-024-02924-9

摘要内容如下：

涉及海马前部的靶向组织消融是耐药性内侧颞叶癫痫患者的标准治疗。然而，即使在手术后，仍有相当一部分人继续遭受癫痫发作的痛苦。我们将小鼠和人类癫痫患者海马尾部后部的灰片吸虫（FC）神经元确定为一个重要的癫痫发作节点。在癫痫小鼠的自发性癫痫发作期间，遗传定义的FC神经元高度活跃，并且这些神经元的闭环光遗传学抑制有效地减少了癫痫发作持续时间。此外，我们在6名癫痫患者的队列研究中发现，FC在癫痫发作期间具有显著的作用。特别是，患者FC的靶向损伤减少了前内侧颞叶结构消融后出现的癫痫发作负担。因此，FC可能是癫痫的一个很有前途的介入靶点。

英文原文如下：

Abstracts

Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the fasciola cinereum (FC) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy. Genetically defined FC neurons were highly active during spontaneous seizures in epileptic mice, and closed-loop optogenetic inhibition of these neurons potently reduced seizure duration. Furthermore, we specifically targeted and found the prominent involvement of FC during seizures in a cohort of six patients with epilepsy. In particular, targeted lesioning of the FC in a patient reduced the seizure burden present after ablation of anterior mesial temporal structures. Thus, the FC may be a promising interventional target in epilepsy.

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